NON‐POSTURAL SERIAL CHANGES IN RENAL FUNCTION DURING THE THIRD TRIMESTER OF NORMAL HUMAN PREGNANCY

M. Ezimokhai, J. M. Davison, P. R. Philips, W. Dunlop

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Seventeen healthy women were investigated near the beginning and again near the end of the third trimester of their normal pregnancies. Infusion studies were performed in the left lateral position. There was a highly significant decrease in effective renal plasma flow but not in glomerular filtration rate, measured as inulin clearance. Plasma creatinine concentration increased significantly, but the renal handling of creatinine was unchanged; simultaneous 24‐hour creatinine clearance showed a tendency to decrease. Serum urate concentration also increased significantly, apparently due to an increase in net tubular reabsorption of urate.

Original languageEnglish
Pages (from-to)465-471
Number of pages7
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Volume88
Issue number5
DOIs
Publication statusPublished - May 1981

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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