No evidence for the involvement of XMRV or MCV in the pathogenesis of breast cancer

G. Khan, P. S. Philip, M. Naase, K. M.I. Al Zarouni

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background: The aetiology of breast cancer remains elusive. A viral aetiology has been proposed, but to date no virus has been conclusively demonstrated to be involved. Recently, two new viruses, namely Merkel cell polyomavirus (MCV) and xenotropic murine leukaemia virus-related virus (XMRV) have been identified and implicated in the pathogenesis of Merkel cell carcinoma (MCC) and familial form of prostate cancer, respectively. Methods: We examined 204 samples from 58 different cases of breast cancer for presence of MCV or XMRV by PCR. Samples consisted of both malignant and non-malignant tissues. Additionally, we included 6 cases of MCC and 12 cases of prostate cancer as potential controls for MCV and XMRV, respectively. Results :All of the breast cancer samples examined were negative for both MCV and XMRV. However, 4/6 MCC and 2/12 prostate cancer samples were found to be positive for MCV and XMRV, respectively. Sequence analysis of the amplified products confirmed that these sequences belonged to MCV and XMRV. Conclusion: We conclude that there is no evidence for the involvement of MCV or XMRV in the pathogenesis of breast cancer. What role these viruses have in the pathogenesis of MCC and prostate carcinomas remains to be demonstrated.

Original languageEnglish
Pages (from-to)1166-1170
Number of pages5
JournalBritish Journal of Cancer
Volume106
Issue number6
DOIs
Publication statusPublished - Mar 13 2012

Keywords

  • MCV
  • Merkel cell carcinoma
  • XMRV
  • breast cancer
  • prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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