Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations

Harriet L. Robinson, David C. Montefiori, R. Paul Johnson, Kelledy H. Manson, Marcia L. Kalish, Jeffrey D. Lifson, Tahir A. Rizvi, Shan Lu, Shiu Lok Hu, Gail P. Mazzara, Dennis L. Panicali, James G. Herndon, Rhona Glickman, Maria A. Candido, Shari L. Lydy, Michael S. Wyand, Harold M. McClure

Research output: Contribution to journalArticlepeer-review

356 Citations (Scopus)

Abstract

Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain.

Original languageEnglish
Pages (from-to)526-534
Number of pages9
JournalNature Medicine
Volume5
Issue number5
DOIs
Publication statusPublished - May 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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