Neuroprotective effects of leptin in vivo and in vitro

Eleni Dicou, Samir Attoub, Pierre Gressens

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)

Abstract

The present study explored the efficacy of leptin in protecting against in vivo induction of excitotoxic lesions by the glutamatergic analogue ibotenate injected into the developing mouse brain and against in vitro NMDA-induced cell death in primary neuronal cultures. Ibotenate injected intracerebrally (i.c.) to mice on postnatal day 5 produced transcortical necrosis and white matter cysts. Co-treatment with leptin administered i.c. or i.p. reduced ibotenate-induced cortical lesions and white matter cysts by 50%. In vitro, leptin afforded significant neuroprotection of mouse cortical neurons against NMDA cytotoxicity. The neuroprotective effect of leptin was antagonized both in vivo and in vitro by the Jak2 inhibitor AG490, indicating that it was mediated via the leptin receptor and Jak2 activation. These findings are the first evidence for a role of leptin in neuroprotection.

Original languageEnglish
Pages (from-to)3947-3951
Number of pages5
JournalNeuroReport
Volume12
Issue number18
DOIs
Publication statusPublished - Dec 21 2001
Externally publishedYes

Keywords

  • Brain lesion
  • Ibotenate
  • Leptin
  • NMDA
  • Neuronal cultures
  • Newborn mouse

ASJC Scopus subject areas

  • Neuroscience(all)

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