NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS

T. E. Adrian, G. Terenghi, M. J. Brown, J. M. Allen, A. J. Bacarese-Hamilton, J. M. Polak, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

134 Citations (Scopus)

Abstract

Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic chain and 55 pmol/l in healthy controls. Since plasma NPY is straighforward to measure and relatively stable, its estimation may prove helpful as a screening test for phaeochromocytoma.

Original languageEnglish
Pages (from-to)540-542
Number of pages3
JournalThe Lancet
Volume322
Issue number8349
DOIs
Publication statusPublished - Sep 3 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS'. Together they form a unique fingerprint.

Cite this