N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

Oscar M. Bautista-Aguilera, Abdelouahid Samadi, Mourad Chioua, Katarina Nikolic, Slavica Filipic, Danica Agbaba, Elena Soriano, Lucía De Andrés, María Isabel Rodríguez-Franco, Stefano Alcaro, Rona R. Ramsay, Francesco Ortuso, Matilde Yañez, José Marco-Contelles

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55 Citations (Scopus)

Abstract

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.

Original languageEnglish
Pages (from-to)10455-10463
Number of pages9
JournalJournal of Medicinal Chemistry
Volume57
Issue number24
DOIs
Publication statusPublished - Dec 26 2014
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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