Myrcene attenuates renal inflammation and oxidative stress in the adrenalectomized rat model

Azim Ullah Shamsul Islam, Björn Hellman, Fred Nyberg, Naheed Amir, Richard L. Jayaraj, Georg Petroainu, Abdu Adem

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

PhysiologicalGlucocorticoids are important regulators of the immune system. Pharmacological GCs are in widespread use to treat inflammatory diseases. Adrenalectomy (ADX) has been shown to exacerbate renal injury through inflammation and oxidative stress that results in renal impairment due to depletion of GCs. In this study, the effect of myrcene to attenuate renal inflammation and oxidative stress was evaluated in the adrenalectomized rat model. Rats were adrenalectomized bilaterally or the adrenals were not removed after surgery (sham). Myrcene (50 mg/kg body weight, orally) was administered post ADX.Myrcene treatment resulted in significant downregulation of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) compared to untreated ADX rats. In addition, myrcene resulted in significant downregulation of immunomodulatory factors (IFN and NF-κB) and anti-inflammatory markers (IL-4 and IL-10) in treated ADX compared to untreated ADX.Myrcene significantly increased the antioxidant molecules (CAT, GSH, and SOD) and decreasedMDA levels in treated ADX compared to untreated. Moreover, myrcene treatment reduced the expression of COX-2, iNOS, KIM-1, and kidney functional molecules (UREA, LDH, total protein, and creatinine) in ADX treated compared to ADX untreated. These results suggest that myrcene could be further developed as a therapeutic drug for treatment of kidney inflammation and injury.

Original languageEnglish
Article number4492
JournalMolecules
Volume25
Issue number19
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Adrenalectomy
  • Glucocorticoids
  • Inflammation
  • Kidney injury molecule
  • Oxidative stress
  • Th1 and Th2 cytokines

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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