Myocardial salvaging effects of Ocimum sanctum in experimental model of myocardial necrosis: A haemodynamic, biochemical and histoarchitectural assessment

D. S. Arya, M. Nandave, S. K. Ojha, S. Kumari, S. Joshi, I. Mohanty

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The present study envisages evaluation of the cardioprotective efficacy of Ocimum sanctum (Os) (Tulsi) in the experimental model of isoproterenol (ISP)-induced myocardial necrosis. Wistar male albino mature rats were randomly divided into four main groups: sham, ISP-control, Os control and Os-treated. Os-control and Os-treated groups were further divided into three subgroups and administered with 25, 75 and 150 mg/kg Os orally, once daily for a month. On the 29th and 30th day, animals of the ISP-control and Os-treated groups received ISP (85 mg/kg) subcutaneously at an interval of 24 h. On the 31st day, 24 h after the second dose of ISP, the haemodynamic variables were recorded and the animals were sacrificed for biochemical and histopathological studies. Significant ventricular dysfunction, myocardial necrosis and depletion of endogenous antioxidants were observed in the ISP-control group compared to sham. Os pre-treatment augmented the basal endogenous antioxidants and restored the antioxidant status of the heart. The myocardial salvaging beneficial effects also translated into functional recovery of the myocardium. Histopathological studies further confirm its myocardial salvaging effects. Our study emphasizes the cardioprotective effect of Os against ISP-induced myocardial necrosis. The present study has demonstrated the cardioprotective effects of Os, which likely result from improved ventricular function, augmentation of endogenous antioxidants and suppression of oxidative stress.

Original languageEnglish
Pages (from-to)667-672
Number of pages6
JournalCurrent Science
Volume91
Issue number5
Publication statusPublished - Sep 10 2006
Externally publishedYes

Keywords

  • Antioxidants
  • Isoproterenol
  • Medicinal herbs
  • Myocardial infarction
  • Ocimum sanctum

ASJC Scopus subject areas

  • General

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