Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility

Anatoly Shmygol, Joanna Gullam, Andrew Blanks, Steven Thornton

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)

Abstract

Oxytocin is a small peptide hormone with multiple sites of action in human body. It regulates a large number of reproduction-related processes in all species. Particularly important is its ability to stimulate uterine contractility. This is achieved by multiple mechanisms involving sarcoplasmic reticulum CaCa2+ release and sensitization of the contractile apparatus to Ca2+. In this paper, we review the data published by us and other groups on oxytocin-induced modulation of uterine contractility. We conclude that sensitization of contractile apparatus to CaCa2+ is the most relevant physiological effect of oxytocin on human myometrium.

Original languageEnglish
Pages (from-to)827-832
Number of pages6
JournalActa Pharmacologica Sinica
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2006
Externally publishedYes

Keywords

  • Calcium sensitization
  • Intracellular calcium
  • Oxytocin
  • Sarcoplasmic reticulum
  • Uterus

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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