Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate

Elena Soriano, Abdelouahid Samadi, Mourad Chioua, Cristóbal de los Ríos, José Marco-Contelles

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

In silico analysis of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate (2) predicts that this molecule should be successfully docked in the PAS, and easily accommodated in the CAS of AChE. The synthesis and the AChE/BuChE inhibition studies are reported, confirming that compound 2 is a potent and selective AChE inhibitor, and consequently, a new lead compound for further development into new dual CAS/PAS cholinergic agents for the treatment of Alzheimer's disease.

Original languageEnglish
Pages (from-to)2950-2953
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number9
DOIs
Publication statusPublished - May 1 2010
Externally publishedYes

Keywords

  • AChE/BuChE inhibition
  • Alzheimer's disease
  • Ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
  • Molecular modelling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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