Microbial source of melatonin and its clinical aspects

Sanjay Kumar, Brendan Patrick Mulligan, Shreesh Ojha, Alex Tinson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Melatonin chemically known as N-acetyl-5-methoxytryptamine is a small physiological compound of diversified functions. Melatonin has been found in phylogenetically different taxa of bacteria, unicellular eukaryote, microalgae, plants, fungi, and animals. Identification of melatonin in many of these microorganisms is missing, and its function is rarely known. Although, melatonin in microorganisms is not essentially involved in circadian process, rather, it exhibits antioxidant property also and may protect chlorophyll pigment to damage from stress and free radicals. Mostly, the pathway for melatonin synthesis in microorganisms shows similarity with vertebrates. Investigation on melatonin in some organisms allows more concrete discussion about their possible role. The various functions of melatonin in human including sleep and regulation of circadian rhythm has been well characterized. Here, we have focused on the mechanism of immune regulatory, antioxidant, and scavenging property of melatonin during pathogenesis caused by fungi, bacteria, and virus. This article will provide a view on microbial sources and possible therapeutic aspects of melatonin in future.

Original languageEnglish
Title of host publicationBiomedicine, Agriculture and Industry
PublisherSpringer International Publishing
Pages39-53
Number of pages15
Volume2
ISBN (Electronic)9783319526690
ISBN (Print)9783319526683
DOIs
Publication statusPublished - Apr 17 2017

Keywords

  • Antioxidant property
  • Circadian process
  • Immune regulation
  • Melatonin
  • Scavenger of free radicals

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Health Professions(all)

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