This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times. Group I received 100 nM POX, Group 2 received 50 μM MCP. Group 3 received 100 nM POX + 50 μM MCP. Red blood cell acetylcholinesterase measurements were performed at base line and then after each 7-d cycle. Enzyme activities were compared using the Mann-Whitney rank order test. Metoclopramide conferred significant in vivo protection from inhibition of RBC-AChE by POX.
|Number of pages||3|
|Journal||Veterinary and Human Toxicology|
|Publication status||Published - Oct 2003|
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis