Metabolism of selegiline [(-)-Deprenyl)]

H. Kalász, K. Magyar, É Szöke, E. Adeghate, A. Adem, M. Y. Hasan, S. M. Nurulain, K. Tekes

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Selegiline (1) [(-)-deprenyl] is used to treat patients with Parkinson's disease. Nevertheless, in much higher doses it has beneficial effects in depression, and dementia of the aged patients. Selegiline (1) undergoes a complex metabolic pathway. Its major metabolites include (-)-desmethyldeprenyl (2), (-)-methamphetamine (3) and (-)-amphetamine (4), deprenyl-N-oxide (5) and formaldehyde (6) as a small metabolic fragment. In addition, more than 40 minor metabolites of selegiline (1) have also been either detected or proposed by investigators and researchers. This review analyses the pharmacological activity, generation pathway and the detection method of the major metabolites of selegiline (1).

Original languageEnglish
Pages (from-to)1522-1530
Number of pages9
JournalCurrent Medicinal Chemistry
Volume21
Issue number13
DOIs
Publication statusPublished - Apr 2014

Keywords

  • (-)-Amphetamine
  • (-)-Desmethyldeprenyl
  • (-)-Methamphetamine
  • Deprenyl-N-oxide
  • Formaldehyde
  • Selegiline

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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