Metabolism of hexachlorobenzene in the fry of steelhead trout, Salmo gairdneri (Oncorhynchus mykiss)

L. Frankovic, M. A.Q. Khan, S. M.Al Ghais

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Dietary intake of hexachlorobenzene (HCB) by steelhead trout (Salmo gairdneri) fry required 12 to 14 days to reach steady state equilibrium. On cessation of feeding, half of the absorbed HCB was eliminated in seven days and half of the remaining HCB in the following three days. The fry (10-gm body wt) during the exposure phase metabolized HCB to very low levels of pentachlorophenol (PCP), which was conjugated further with glucuronic acid. PCP was also produced in vitro by hepatic microsomal P-450 of the larger fry. The small 1-gm fry at the end of the experiment (20 days post-exposure) showed traces of only 2,5-dichloro-, 2,3,6,-trichloro- and 2,4,5-trichloro-phenol.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalArchives of Environmental Contamination and Toxicology
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 1 1995

ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Metabolism of hexachlorobenzene in the fry of steelhead trout, Salmo gairdneri (Oncorhynchus mykiss)'. Together they form a unique fingerprint.

Cite this