Medicinal chemistry of antiviral/anticancer prodrugs subjected to phosphate conjugation

H. Kalász, A. Adem, M. Y. Hasan, E. Adeghate, N. Ram, Z. Gulyás, K. Tekes

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Certain xenobiotics are given in the "prodrug" form. Either the human body, or one compartment of the body, or the targeted virus itself metabolizes the prodrug into its active form. The bioprecursor form of drugs is used for a wide variety of reasons, namely: to make drug penetration into the target organ (mainly to the brain through the blood-brain- barrier) possible, eliminate unpleasant taste, alter (either increasing or decreasing) the half life of the active component or supply more than one active components to the body.

Original languageEnglish
Pages (from-to)822-845
Number of pages24
JournalMini-Reviews in Medicinal Chemistry
Volume10
Issue number9
DOIs
Publication statusPublished - Jan 1 2010

Keywords

  • Anticancer
  • Antiviral
  • Bioprecursor
  • Conjugation
  • Medicinal chemistry
  • Phosphate
  • Prodrug

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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