Mechanisms of Mediator complex action in transcriptional activation

Suraiya A. Ansari, Randall H. Morse

Research output: Contribution to journalReview articlepeer-review

71 Citations (Scopus)

Abstract

Mediator is a large multisubunit complex that plays a central role in the regulation of RNA Pol II transcribed genes. Conserved in overall structure and function among eukaryotes, Mediator comprises 25-30 protein subunits that reside in four distinct modules, termed head, middle, tail, and CDK8/kinase. Different subunits of Mediator contact other transcriptional regulators including activators, co-activators, general transcription factors, subunits of RNA Pol II, and specifically modified histones, leading to the regulated expression of target genes. This review is focused on the interactions of specific Mediator subunits with diverse transcription regulators and how those interactions contribute to Mediator function in transcriptional activation.

Original languageEnglish
Pages (from-to)2743-2756
Number of pages14
JournalCellular and Molecular Life Sciences
Volume70
Issue number15
DOIs
Publication statusPublished - Aug 2013
Externally publishedYes

Keywords

  • Co-activator
  • Mediator
  • SAGA
  • Swi/Snf
  • Transcription

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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