Label-free capacitance-based identification of viruses

Mahmoud Al Ahmad, Farah Mustafa, Lizna M. Ali, Jimsheena V. Karakkat, Tahir A. Rizvi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

This study was undertaken to quantitate a single virus suspension in culture medium without any pre-processing. The electrical capacitance per virus particle was used to identify the kind of virus present by measuring the suspension (virus plus medium) capacitance, de-embedding the medium contribution, and dividing by the virus count. The proposed technique is based on finding the single virus effective dielectric constant which is directly related to the virus composition. This value was used to identify the virus type accordingly. Two types of viruses thus tested were further quantified by a biochemical technique to validate the results. Furthermore, non-organic nanoparticles with known concentration and capacitance per particle were identified using the proposed method. The selectivity of the method was demonstrated by performing electrical measurements on a third virus, revealing that the proposed technique is specific and sensitive enough to permit detection of a few hundred virus particles per milliliter within a few minutes.

Original languageEnglish
Article number9809
JournalScientific reports
Volume5
DOIs
Publication statusPublished - May 13 2015

ASJC Scopus subject areas

  • General

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