Is raised plasma peptide YY after intestinal resection in the rat responsible for the trophic response?

A. P. Savage, G. E. Gornacz, T. E. Adrian, M. A. Ghatei, R. A. Goodlad, N. A. Wright, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28±3-1 to 85±12·3 pmol/l (p<0.001) and this difference was maintained to 48 days. Plasma PYY correlates both with crypt cell production rate (CCPR) in the ileum and with plasma enteroglucagon levels. In a second study, PYY or saline was infused over a 12 day period. There were no significant changes in intestinal wet weight or CCPR in any part of the bowel studied. This indicates that it is unlikely that PYY exerts a major trophic effect on the gastrointestinal tract.

Original languageEnglish
Pages (from-to)1353-1358
Number of pages6
JournalGut
Volume26
Issue number12
DOIs
Publication statusPublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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