Is EBV persistence in vivo a model for B cell homeostasis?

Gulfaraz Khan, Emily M. Miyashita, Bin Yang, Gregory J. Babcock, David A. Thorley-Lawson

Research output: Contribution to journalArticlepeer-review

141 Citations (Scopus)

Abstract

We have measured the absolute numbers of EBV-infected B cells in the peripheral blood of healthy persistently infected individuals. Single measurements on a panel of 15 healthy individuals demonstrate that the frequency varies over a wide range from 1-50 per 106 B cells. Repeat measurements over 1-3.5 years on several individuals whose frequencies varied over a 10-fold range showed that the variation does not represent the fluctuation in the frequency that can occur within an individual; rather, the frequencies are specific to the individual. The frequency within an individual measured over time is stable and contributes less than 10% to the variance seen in the whole population. These measurements suggest that the level of EBV-infected B cells is tightly regulated and we propose that the same homeostatic mechanisms that regulate the levels of normal B cells also regulate B cells latently infected with EBV.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalImmunity
Volume5
Issue number2
DOIs
Publication statusPublished - Aug 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Is EBV persistence in vivo a model for B cell homeostasis?'. Together they form a unique fingerprint.

Cite this