Iosimenol, a new non-ionic dimeric contrast medium, does not induce immunoreactivity in the popliteal lymph node assay

M. J. Fernandez Cabezudo, G. Petroianu, B. Al-Ramadi, Ruth D. Langer

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Animal studies in mice were conducted to determine the potential immunoreactivity of the new non-ionic dimeric contrast medium (CM) iosimenol using the PLNA and flow cytometric analyses. Comparative studies were performed with iodixanol. The known immune-reactive substance strepozotocin (STZ) and vehicle injections served as positive and negative controls, respectively. Our experiments did not show any immunological effect of iosimenol, concluding that the new CM iosimenol may be beneficial for use in high-risk patients.

Original languageEnglish
Pages (from-to)713-718
Number of pages6
JournalBritish Journal of Radiology
Volume80
Issue number957
DOIs
Publication statusPublished - Sep 2007
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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