Interactions of quercetin with receptor tyrosine kinases associated with human lung carcinoma

Bincy Baby, Priya Antony, Ranjit Vijayan

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Lung cancer is a deadly form of cancer with high morbidity and mortality rates. Deregulated receptor tyrosine kinases (RTKs) are frequently associated with the formation and development of lung carcinoma. Quercetin is a major dietary flavonoid that has been shown to induce cell growth inhibition and apoptosis in human lung cancer cell lines. In the current study, four major overexpressed RTKs–EGFR, FGFR1, IGF1R and c-Met–involved in human lung cancer were investigated. Molecular docking was employed to identify the binding orientation and inhibitory potential of quercetin in these RTKs. Quercetin bound to the ATP binding pocket of these kinases exhibited good binding scores and interactions by establishing hydrogen, hydrophobic and π-π interactions with the hinge region and the DFG motif in the activation loop. Thus, quercetin could be further explored as a platform for developing specific or polypharmacological compounds targeting overexpressed RTKs in lung cancer.

Original languageEnglish
Pages (from-to)2928-2931
Number of pages4
JournalNatural Product Research
Volume32
Issue number24
DOIs
Publication statusPublished - Dec 17 2018

Keywords

  • Quercetin
  • lung cancer
  • molecular docking
  • receptor tyrosine kinases

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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