Insulin releasing properties of the temporin family of antimicrobial peptides

Yasser H.A. Abdel-Wahab, Lamin Marenah, Peter R. Flatt, J. Michael Conlon

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Temporin-1Vb, -1Oe, -1DRb, and -1TGb (10-8 - 10-6M) produced significant (p<0.05) and concentration-dependent stimulatory effects on insulin secretion from clonal rat BRIN-BD11 cells without increased release of lactate dehydrogenase. Temporin-1Va and temporin-1Vc (10-8 - 10-6M) also stimulated insulin-release but were cytotoxic at 10 -6M. Temporin-1DRa was without effect. The temporins at 10 -7 M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a KATP channel- independent pathway.

Original languageEnglish
Pages (from-to)702-707
Number of pages6
JournalProtein and Peptide Letters
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Keywords

  • Amphibian skin
  • Cytolysis
  • Insulin secretion
  • Temporin

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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