Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization

A. Adem, S. S. Jossan, R. d'Argy, P. G. Gillberg, A. Nordberg, B. Winblad, V. Sara

Research output: Contribution to journalArticlepeer-review

107 Citations (Scopus)

Abstract

The distribution of Insulin-like growth factor 1 (IGF-1) receptors in large cryosections of human brain hemispheres (80-μm) was studied by quantitative autoradiography using 125I-IGF-1 as ligand. Postmortem tissue only from individuals free from neurological diseases was used. The highest densities of IGF-1 receptors were found in the hippocampus, amygdala and parahippocampal gyrus. Intermediate densities were observed in the cerebellum, cerebral cortex and caudate nucleus, whereas low densities of IGF-1 receptors were obtained in the substantia nigra, red nucleus, white matter and cerebral pedunculus. The cartography of IGF-1 receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.

Original languageEnglish
Pages (from-to)299-303
Number of pages5
JournalBrain Research
Volume503
Issue number2
DOIs
Publication statusPublished - Dec 4 1989
Externally publishedYes

Keywords

  • Brain hemisphere
  • Human brain
  • Image analysis
  • Insulin-like growth factor-1
  • Large cryosection
  • Quantitative autoradiography
  • Receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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