Influence of inclusion complexation with β-cyclodextrin on the photostability of selected imidazoline-derived drugs

Abdulilah Dawoud Bani-Yaseen, Nathir F. Al-Rawashdeh, Idrees Al-Momani

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

In this paper, the influence of inclusion complexation with β-cyclodextrin (β-CD) on the photostability of antazoline, xylometazoline, and naphazoline in aqueous media was investigated. The photodegradation reaction of these drugs molecules was explored using UV-vis spectrophotometery-based kinetic analysis and high performance liquid chromatography (HPLC). Quantitative evaluation of the influence of β-CD was judged based on the observed rate constant (kobs), half-life time (t0.5) and t0.1 of the photodegradation reaction and the peak area of the corresponding analyte after photodegradation using HPLC separation. It has been demonstrated that the photostability of these selected imidazoline-based drugs has been enhanced upon forming inclusion complexes with β-CD in aqueous media. Moreover, high consistency regarding the photostability enhancement was obtained using both techniques. Hypothetical structure for 1:1 inclusion complexes was proposed based on molecular mechanics calculations, which in turn provide an insight for the energetically preferential structure of the inclusion complexes. The results obtained demonstrate that β-CD can be utilized as photostabilizer additive for enhancing the photostability of imidazoline-derived drugs molecules.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
Volume63
Issue number1-2
DOIs
Publication statusPublished - Feb 2009

Keywords

  • Imidazoline-derived drugs
  • Inclusion complexes
  • Photodegradation
  • Photostability
  • β-Cyclodextrin

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

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