Immunophenotype of hairy‐cell leukemia

I. B. Hassan, H. Hagberg, C. Sundström

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B‐cell phenotype different from that of B‐CLL was observed (CD10, CD19+, CD20+, CD21, CD22+, CD37+, CD38, FMC7+, LN1+, PCA‐1+, BLy7+and CD5). As expected, CD11c and CD25 were positive and, in addition, a My7 and My9 positivity in varying degree was noted. 3 weeks of in vitro incubation did not significantly alter the phenotype. We conclude that HCL exhibits a unique phenotype among chronic B‐cell leukemias, which is closer to the plasma cell stage of differentiation than that of B‐CLL. The BLy7 monoclonal antibody seems to be a promising marker for HCL.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalEuropean Journal of Haematology
Volume45
Issue number3
DOIs
Publication statusPublished - Sep 1990
Externally publishedYes

Keywords

  • BLy7
  • hairy cell leukemia
  • immunophenotype
  • monoclonal antibodies

ASJC Scopus subject areas

  • Hematology

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