Immune response against lipopolysaccharide and invasion plasmid-coded antigens of shigellae in Vietnamese and Swedish dysenteric patients

Dac Cam Phung Dac Cam, T. Pal, A. A. Lindberg

Research output: Contribution to journalComment/debatepeer-review

35 Citations (Scopus)

Abstract

The peripheral immune responses of adult Vietnamese patients infected with Shigella dysenteriae 1 and Shigella flexneri 1b and 2a and those of S. flexneri-infected Swedish patients were studied against various lipopolysaccharide and invasion plasmid-coded antigens (Ipa-s) and compared with the titers for the corresponding local healthy populations. Both Vietnamese and Swedish patients reacted with significant (P, <0.05) titer increases in the immunoglobulin A and G classes against the homologous lipopolysaccharide antigen. However, significant titer responses against the Ipa-s were seen among only the Swedish patients. We surmise that the weak- to-moderate responses against the Ipa-s in Vietnamese patients are due to the fact that the high level of titers induced by previous infections in the local population could not be considerably increased further by a recent infection.

Original languageEnglish
Pages (from-to)454-457
Number of pages4
JournalJournal of Clinical Microbiology
Volume31
Issue number2
DOIs
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)

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