Hypoxia-inducible factor-1 alpha in the heart: A double agent?

Satwat Hashmi, Suhail Al-Salam

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

Hypoxia-inducible factor (HIF) is a set of transcription factors that regulate the cellular response to hypoxia. There is a great body of evidence supporting the protective role of HIF-1α in cardiovascular pathophysiology, however, newer studies are hinting at a maladaptive and deleterious role of this transcription factor that merits further investigation. There is a general agreement, however, that HIF-mediated responses appear to differ under conditions of acute and chronic oxygen deprivation. The intensity and sustainability of HIF-1α activation are major determinants of whether the responses are pathological or beneficial. HIF activation is seen to be beneficial in the setting of acute myocardial ischemia and deleterious in chronic conditions. In this review, we will focus on recent insights into the role of HIF-1α in the heart and especially in the setting of ischemic heart disease.

Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalCardiology in Review
Volume20
Issue number6
DOIs
Publication statusPublished - Nov 2012

Keywords

  • HIF-1α
  • heart
  • ischemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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