Human plasma kinetics and relative bioavailability of alkylresorcinols after intake of rye bran

Rikard Landberg, Anna Maria Linko, Afaf Kamal-Eldin, Bengt Vessby, Herman Adlercreutz, Per Åman

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)

Abstract

Alkylresorcinols (ARs) are phenolic lipids present in whole grain and bran of wheat and rye. Chemically, they comprise 1,3-dihydroxy-5-alkylbenzene homologs with odd-numbered, mainly saturated hydrocarbon side chains in the range of 17-25 carbon atoms. ARs are evaluated both for physiological effects and for their potential use as biomarkers of whole-grain wheat and rye intake. In this study, plasma kinetics and relative bioavailability of ARs in humans were investigated after a single intake of rye bran 120 g (190 mg ARs). The shapes of plasma concentration time curves were similar in the subjects (n = 6) with 2 peaks at ∼2.8 and 6.5 h and maximum concentrations (mean ± SEM) of 1253 ± 125 and 3365 ± 309 nmol/L, respectively. The relative bioavailability of different homologs increased with increasing length of the AR side chain (r = 0.97, P < 0.001), indicating differences in metabolism. The apparent half-lives were rather short, ∼5 h for all homologs, which suggests that the AR concentration in plasma could be used as a short- to medium-term biomarker of regular intake of whole-grain wheat and rye.

Original languageEnglish
Pages (from-to)2760-2765
Number of pages6
JournalJournal of Nutrition
Volume136
Issue number11
DOIs
Publication statusPublished - Nov 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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