Human bronchiolar deposition and retention of 6-, 8-, and 10-μm particles

Per Camner, Martin Anderson, Klas Philipson, Adrian Bailey, Adel Hashish, Naomi Jarvis, Michael Bailey, Magnus Svartengren

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Three groups, each consisting of 6 healthy subjects, inhaled, respectively, 6-μm (aerodynamic diameter), 8-μm, and 10-μm Teflon particles, labeled with indium-111. The particles were inhaled at an extremely low flow rate, 0.05 L/s. Lung retention was measured after 0, 24, 48, and 72 h. Two models were used to calculate particle deposition in the lungs in the various generations: the Karolinska Institute model (KI model) and the University of Southampton model (US model). From the experimental clearance data and the theoretical deposition data, it was calculated that the average retention after 24 h was around 100% for particles deposited in generations 13-16 (ciliated bronchioles) and around 20% in generations 0-12 (both large and small ciliated airways). In these calculations, it was assumed that the retained fractions were independent of particle, size. The depositions in the bronchial region (generations 0-8), bronchiolar region (generations 9-15 or 9-16), and the alveolar region were calculated using the two models and compared with the recent ICRP model. On the whole, the three models agreed fairly well.

Original languageEnglish
Pages (from-to)517-535
Number of pages19
JournalExperimental Lung Research
Volume23
Issue number6
DOIs
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Bronchioles
  • Lung retention
  • Mucociliary clearance
  • Particle deposition

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry

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