How viruses hijack and modify the secretory transport pathway

Zubaida Hassan, Nilima Dinesh Kumar, Fulvio Reggiori, Gulfaraz Khan

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remod-eled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to Picornaviridae, Coronaviridae, Flaviviridae, Poxviridae, Parvoviridae and Herpesviridae families.

Original languageEnglish
Article number2535
JournalCells
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Endoplasmic reticulum
  • Golgi
  • Intracellular trafficking
  • Membrane rearrangements
  • Plasma membrane
  • Vesicles
  • Viruses

ASJC Scopus subject areas

  • Medicine(all)

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