Host-defense peptides with therapeutic potential from skin secretions of frogs from the family Pipidae

J. Michael Conlon, Milena Mechkarska

Research output: Contribution to journalReview articlepeer-review

62 Citations (Scopus)

Abstract

Skin secretions from frogs belonging to the genera Xenopus, Silurana, Hymenochirus, and Pseudhymenochirus in the family Pipidae are a rich source of host-defense peptides with varying degrees of antimicrobial activities and cytotoxicities to mammalian cells. Magainin, peptide glycine-leucine-amide (PGLa), caerulein-precursor fragment (CPF), and xenopsin-precursor fragment (XPF) peptides have been isolated from norepinephrine-stimulated skin secretions from several species of Xenopus and Silurana. Hymenochirins and pseudhymenochirins have been isolated from Hymenochirus boettgeri and Pseudhymenochirus merlini. A major obstacle to the development of these peptides as anti-infective agents is their hemolytic activities against human erythrocytes. Analogs of the magainins, CPF peptides and hymenochirin-1B with increased antimicrobial potencies and low cytotoxicities have been developed that are active (MIC < 5 μM) against multidrug-resistant clinical isolates of Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, Stenotrophomonas maltophilia and Klebsiella pneumoniae. Despite this, the therapeutic potential of frog skin peptides as anti-infective agents has not been realized so that alternative clinical applications as anti-cancer, anti-viral, anti-diabetic, or immunomodulatory drugs are being explored.

Original languageEnglish
Pages (from-to)58-77
Number of pages20
JournalPharmaceuticals
Volume7
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Caerulein-precursor fragment
  • Frog skin
  • Hymenochirin
  • Magainin
  • PGLa
  • Xenopsin-precursorfragment

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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