Single, intradermal injections of twenty chemicals resulted in ulceration, wheal, abscess and tumour formation, depilation and permanent hair depigmentation in C57 black, male mice. Depigmentation was observed with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), nitrogen mustard (HN2), many tumour promoters and local application of carbon dioxide snow. Histological examination showed distinct margins separating well-pigmented hair tips from the depigmented bulbs and lower shaft when the chemicals caused complete depigmentation. With chemicals which caused slight depigmentation, such as phenol, patchy loss of pigment was observed in scattered areas. The depigmentation effect may be due to selective toxic action on melanocytes, and is an indication of tumour promoting activity.
|Number of pages||2|
|Journal||IRCS Medical Science|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)