Hepatitis B virus transmission in The Netherlands: A population-based, hierarchical case-control study in a very low-incidence country

Susan J.M. Hahné, I. K. Veldhuijzen, L. J.M. Smits, N. Nagelkerke, M. J.W. van de Laar

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

We report the first population-based case-control study on acute hepatitis B in a very low-incidence country. A case was a Netherlands resident, notified between May 1999 and July 2000 with symptoms and serology compatible with acute hepatitis B. Population controls were randomly selected, with oversampling from men and persons aged 20-39 years. Risk factors were studied using logistical regression, distinguishing confounders and mediators through hierarchical analysis. Participants were 120 cases and 3948 controls. The risk of acute hepatitis B was increased in men who have sex with men, with reporting to have had more than two partners in the past 6 months the only significant risk. In children, adult females and heterosexual males, having parents born in a hepatitis B endemic country was a significant risk. For adult females and heterosexual males, this was largely explained by having a foreign partner. For children this was partly explained by parenteral exposures abroad.

Original languageEnglish
Pages (from-to)184-195
Number of pages12
JournalEpidemiology and Infection
Volume136
Issue number2
DOIs
Publication statusPublished - Feb 2008

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

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