Gut hormone release after intestinal resection

H. S. Besterman, T. E. Adrian, C. N. Mallinson, N. D. Christofides, D. L. Sarson, A. Pera, L. Lombardo, R. Modigliani, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

To investigate the possible role of gut and pancreatic hormones in the adaptive responses to gut resection, plasma concentrations of the circulating hormones were measured, in response to a test breakfast, in patients with either small or large intestinal resection and in healthy control subjects. In 18 patients with partial ileal resection a significant threefold rise was found in basal and postprandial levels of pancreatic polypeptide, a fourfold increase in motilin, and more than a twofold increase in gastrin and enteroglucagon levels compared with healthy controls. In contrast, nine patients with colonic resection had a threefold rise in levels of pancreatic polypeptide only. One or more of these peptides may have a role in stimulating the adaptive changes found after gut resection.

Original languageEnglish
Pages (from-to)854-861
Number of pages8
JournalUnknown Journal
Volume23
Issue number10
DOIs
Publication statusPublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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