Gold nanoparticles chemisorbed by a terphenyldithiol self-assembled monolayer for fabrication of a protein biosensor

Nathir A.F. Al-Rawashdeh, W. Azzam

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

In this study, improved detection of bovine serum albumin (BSA) was achieved by use of a fabricated surface plasmon resonance (SPR) biosensor. Terphenyldithiol (TPDT) was self-assembled on a gold substrate, then gold nanoparticles (Au-NPs) were chemisorbed on to the TPDT monolayer by strong bonding with the terminal thiol groups of the TPDT. The new sensor obtained was tested for immobilization of protein. The SPR results revealed much better detection of BSA by Au-NPs chemisorbed on the TPDT self-assembled monolayer (SAM) than by the bare SAM on the gold substrate.

Original languageEnglish
Pages (from-to)759-770
Number of pages12
JournalResearch on Chemical Intermediates
Volume37
Issue number7
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Gold nanoparticles
  • Protein biosensor
  • Self-assembled monolayers
  • Surface plasmon resonance
  • Terphenyldithiol

ASJC Scopus subject areas

  • Chemistry(all)

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