Genetic analysis of the gene for porcine submaxillary gland mucin: Physical assignment of the MUC and interferon γ genes to chromosome 5

M. Johansson, B. Chowdhary, F. Gu, H. Ellegren, I. Gustavsson, L. Andersson

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Genetic variation at the porcine submaxillary gland mucin (MUC) locus was revealed by RFLP analysis. A three-allele system was defined, and codominant inheritance was confirmed using a three-generation pedigree comprising 10 founder individuals, 26 F1 animals, and 200 F2 offspring. Linkage analysis was performed against a set of 56 genetic markers. The mucin locus was assigned to a previously reported linkage group comprising the markers interferon γ (IFNG), diacylglycerol kinase (DAGK), and an anonymous microsatellite (S0092). Furthermore, the genes for mucin and interferon γ were physically localized to porcine chromosome 5q2.3 and 5p1.2-q1.1 by fluorescence and radioactive in situ hybridization, respectively, thereby assigning four new markers to chromosome 5. This chromosome shares homologies with chromosome 5 in cattle and chromosome 12 in humans.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalJournal of Heredity
Volume84
Issue number4
DOIs
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Genetic analysis of the gene for porcine submaxillary gland mucin: Physical assignment of the MUC and interferon γ genes to chromosome 5'. Together they form a unique fingerprint.

Cite this