Generation of particle assemblies mimicking enzymatic activity by processing of herbal food: The case of rhizoma polygonati and other natural ingredients in traditional Chinese medicine

Enrico Benassi, Haiyan Fan, Qinglei Sun, Kanat Dukenbayev, Qian Wang, Ainur Shaimoldina, Aigerim Tassanbiyeva, Lazzat Nurtay, Ayan Nurkesh, Aidana Kutzhanova, Chenglin Mu, Adilet Dautov, Madina Razbekova, Anar Kabylda, Qing Yang, Ziye Li, Amr Amin, Xugang Li, Yingqiu Xie

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Processed herbs have been widely used in eastern and western medicine; however, the mechanism of their medicinal effects has not yet been revealed. It is commonly believed that a central role is played by chemically active molecules produced by the herbs' metabolism. In this work, processed rhizoma polygonati (RP) and other herbal foods are shown to exhibit intrinsic phosphatase-like (PL) activity bounded with the formation of nano-size flower-shaped assembly.Viaquantum mechanical calculations, an enzymatic mechanism is proposed. The enzymatic activity may be induced by the interaction between the sugar molecules distributed on the surface of the nanoassemblies and the phosphatase substrateviaeither a hydroxyl group or the deprotonated hydroxyl group. Meanwhile, the investigation was further extended by processing some fresh herbs and herbal food through a similar protocol, wherein other enzymatic activities (such as protease, and amylase) were observed. The PL activity exhibited by the processed natural herbs was found to be able to effectively inhibit cancer cell growthviaphosphatase signaling, possibly by crosstalk with kinase signaling or DNA damage by either directly binding or unwinding of DNA, as evidenced by high-resolution atomic-force microscopy (HR-AFM). In this work, the neologism herbzyme (herb + enzyme) is proposed. This study represents the first case of scientific literature introducing this new term. Besides the well-known pharmacological properties of the natural molecules contained in herbs and herbal food, there exists an enzymatic/co-enzymatic activity attributed to the nanosized assemblies.

Original languageEnglish
Pages (from-to)2222-2235
Number of pages14
JournalNanoscale Advances
Volume3
Issue number8
DOIs
Publication statusPublished - Apr 21 2021

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Materials Science(all)
  • Engineering(all)

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