Free radical scanvenging and antioxidant effects of some anthraquinone derivatives

Abderrahmane Baghiani, Noureddine Charef, Meriem Djarmouni, Haythem A. Saadeh, Lekhmici Arrar, Mohammad S. Mubarak

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

In this study, the screening of five anthraquinones (purpurin, xanthopurpurin, rubiadin, kermisic acid and flavokermisic acid), for their free radical scavenging and antioxidant effects was carried out, using three complementary methods. DPPH (2,2-diphenyl-1-picrylhydrazyl) revealed that purpurin has a scavenging effect with IC50 = 3.491 ± 0.014 βg/ml. Results of β-carotene / linoleic acid assay showed that kermisic and flavokermisic acids have significant inhibition of lipid peroxidation with I % = 76.1 ± 1.5 % and 68.6 ± 2.5 %, respectively. In addition, the ferrous ion chelating test showed that only purpurin, with small concentrations, interferes in a dose dependant manner with the formation of Fe2+- ferrozine complex. These results are promising for further studies of the biological and pathological effects of these natural products.

Original languageEnglish
Pages (from-to)639-644
Number of pages6
JournalMedicinal Chemistry
Volume7
Issue number6
DOIs
Publication statusPublished - Nov 2011
Externally publishedYes

Keywords

  • Anthraquinones
  • Antioxidant
  • Free radical
  • Ion chelating
  • Lipid peroxidation
  • Scavenger

ASJC Scopus subject areas

  • Drug Discovery

Fingerprint

Dive into the research topics of 'Free radical scanvenging and antioxidant effects of some anthraquinone derivatives'. Together they form a unique fingerprint.

Cite this