Foscarnet salvage therapy for acyclovir-resistant varicella zoster: Report of a novel thymidine kinase mutation and review of the literature

Todd Hatchette, Graham A. Tipples, Geoff Peters, Ahmed Alsuwaidi, Jianwei Zhou, Timothy Lloyd Mailman

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A novel thymidine kinase mutation is described, along with a new phenotypic assay for characterizing acyclovir resistance in varicella zoster virus.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalPediatric Infectious Disease Journal
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2008
Externally publishedYes

Keywords

  • Acyclovir resistance
  • Foscarnet
  • VZV

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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