Formation of naproxen-polylactic acid nanoparticles from supercritical solutions and their characterization in the aerosol phase

Moritz Gadermann, Simran Kular, Ali H. Al-Marzouqi, Ruth Signorell

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Pure naproxen particles and mixed naproxen-polylactic acid particles were formed by pulsed rapid expansion of supercritical CO2 solutions (RESS). The characterization of the particles was carried out in the aerosol phase as a function of time after particle formation with rapid-scan infrared spectroscopy and with an aerosol particle sizer. After collection of the particles from the aerosol phase, the particles were characterized with scanning electron microscopy and powder diffraction. The present study shows clear evidence that RESS is capable of forming sub-micron naproxen particles that are coated with polylactic acid. Furthermore, it is demonstrated that coating with polylactic acid stabilizes the naproxen particles against agglomeration and coagulation.

Original languageEnglish
Pages (from-to)7861-7868
Number of pages8
JournalPhysical Chemistry Chemical Physics
Volume11
Issue number36
DOIs
Publication statusPublished - Sep 14 2009

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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