Fluorinated steroids and their derivatives

Yosef Al Jasem, Thies Thiemann, Lurdes Gano, Maria Cristina Oliveira

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Fluorinated steroids have found entry into the list of important pharmaceuticals. Fluorinated corticosteroids are being used as topical drugs against rheumatism and inflammatory skin diseases or as inhalation drugs again asthma. A number of fluorinated steroids bind strongly to the estrogen or the progesterone receptor. With the availability of [18F]fluorine as a radiolabel, radiofluorinated steroids are being developed as potential positron emission tomography (PET) imaging agents. This article presents an overview of preparative methods to fluorinated steroids as well as of the uses of these compounds.

Original languageEnglish
Pages (from-to)48-85
Number of pages38
JournalJournal of Fluorine Chemistry
Volume185
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Corticosteroids
  • Estrogen receptor ligands
  • Fluorination
  • Positron emission tomography (PET)
  • Radiolabelling

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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