Flat epithelial atypia in a mammary hamartoma: Case report & clinicopathologic correlates

Alia Saeed Albawardi, Sheikha Mohammed Al Sharri, Mohammed Al Bashir, Saeeda Saleh Almarzooqi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Mammary hamartoma is a rare benign breast neoplasm, composed of all breast tissue elements in variable proportions. It accounts for 4. 8% of benign mammary tumors. Herein, we present a case of a 42-year-old woman who underwent right breast lumpectomy for a solitary well defined breast tumor. Histologic features were consistent with mammary hamartoma and an associated columnar cell changes including flat epithelial atypia. This is, to the best of our knowledge, the first reported case of such an association/finding. The paper will highlight the clinico-pathologic and molecular characteristics of hamartomas in general and summarize the current understanding on it’s the pathogenesis.

Original languageEnglish
Pages (from-to)4896-4900
Number of pages5
JournalInternational Journal of Clinical and Experimental Medicine
Volume9
Issue number2
Publication statusPublished - Feb 29 2016

Keywords

  • Columnar cell changes
  • Columnar cell hyperplasia
  • Estrogen receptor (ER)
  • Flat epithelial atypia
  • Human epidermal growth factor receptor 2 (Her2/neu)
  • Lobular neoplasia
  • Mammary hamartoma
  • Progesterone receptor (PR)
  • Pseudoangiomatous hyperplasia

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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