Fabrication of porous bone scaffolds using alginate and bioactive glass

Jonathan Hatton, Graham Roy Davis, Abdel Hamid I. Mourad, Nizamudeen Cherupurakal, Robert G. Hill, Sahar Mohsin

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Porous composite scaffold using an alginate and bioactive glass ICIE16M was synthesized by a simple freeze-drying technique. The scaffold was characterized using compression testing, Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD), X-ray microtomography (XMT) and scanning electron microscopy (SEM). The bioactivity of the scaffold was evaluated by its ability to form apatite on its surface in simulated body fluid (SBF). The data collected showed evidence that the novel material produced had an appropriate pore size for osteoconduction, with an average pore size of 110 µm and maximum pore size of 309 µm. Statistical analysis confirmed that the glass filler significantly (p < 0.05) increased the collapse yield of the scaffolds compared with pure alginate scaffolds. The ICIE16M glass had an amorphous structure, favorable for bioactivity.

Original languageEnglish
Article number15
JournalJournal of Functional Biomaterials
Volume10
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • Alginate
  • Bioactive glass
  • Bone scaffolds
  • Freeze-drying
  • Porous
  • Strontium

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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