Evaluation of the accuracy and precision of lung aerosol deposition measurements from planar radionuclide imaging using simulation

John S. Fleming, J. H. Conway, S. T. Holgate, E. A. Moore, A. H. Hashish, A. G. Bailey, T. B. Martonen

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Planar images of known, theoretical distributions of radioaerosol in the lung have been simulated using lung models derived from magnetic resonance studies on human subjects. Total lung activity was evaluated from the simulated images together with the absolute penetration index (PI) and a relative value expressed as a fraction of that in a simulated ventilation image. The accuracy and precision of these measurements were calculated by comparison with the true values used in the simulation. Total activity was assessed with systematic errors within 5% and precision within 6.5%. Measured PIs varied only slowly with true PI and inter-model variation masked changes between measurements on the different distributions. The relative PI reduced inter-model variation and provided significant differences between all the distributions. PI was significantly affected by misalignment of the lung region of interest. The conducting airways deposition fraction (CADF) used in the simulation correlated linearly with the fractional activity in a central tung region, allowing CADF to be estimated with a precision of 21%.

Original languageEnglish
Pages (from-to)2423-2429
Number of pages7
JournalPhysics in Medicine and Biology
Volume43
Issue number8
DOIs
Publication statusPublished - Aug 24 1998
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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