Enhanced localization of amyloid β precursor protein in the rat hippocampus following long-term adrenalectomy

A. Islam, R. N. Kalaria, B. Winblad, A. Adem

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Using various antibodies to the amyloid β precursor protein (APP) associated with Alzheimer's disease, we investigated changes in the distribution of APP in the hippocampus and neocortex of adrenalectomized (ADX) rats. In contrast to sham-operated controls, ADX rats euthanised after a survival period of 5 months showed striking APP reactivity in the CA1-CA4 fields and in the surviving cells in the dentate gyms. Our results suggest the enhanced APP reactivity in hippocampal neurons may pertain to previous observations on the accumulation of APP fragments in the neocortex during ischemic or traumatic injury. Thus, long-term hormone deprivation would be another factor, which may influence the expression of APP in brain.

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalBrain Research
Volume806
Issue number1
DOIs
Publication statusPublished - Sep 21 1998
Externally publishedYes

Keywords

  • Adrenalectomy
  • Alzheimer's disease
  • Amyloid protein precursor
  • Glucocorticoid
  • Hippocampus
  • Vascular cell

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Enhanced localization of amyloid β precursor protein in the rat hippocampus following long-term adrenalectomy'. Together they form a unique fingerprint.

Cite this