Effects of Roselle and Ginger on cisplatin-induced reproductive toxicity in rats

Amr Amin, Alaa Eldin A. Hamza

Research output: Contribution to journalArticlepeer-review

132 Citations (Scopus)

Abstract

Aim: To evaluate the protective effects of Hibiscus sabdariffa (Roselle) and Zingiber officinale (Ginger) against cisplatin-induced reproductive toxicity in rats and to study the mechanisms underlying these effects. Methods: Ethanol extracts of H. sabdariffa or Z. officinale [1 g/ (kg...day)] were given p.o. to male albino rats for 26 days, which began 21 days before a single cisplatin i.p. injection (10 mg/kg body weight). Results: Extracts of H. sabdariffa and Z. officinale reduced the extent of cisplatin-induced sperm abnormality and enhanced sperm motility. Both extracts restored the control level of malondialdehyde (MDA) (lipid peroxidation marker) in the cisplatin-treated testis. The cisplatin injection induced decline in the levels of superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) were significantly reversed to control levels in groups where cisplatin was preceded by the administration of either H. sabdariffa or Z. officinale. Conclusion: Both H. sabdariffa and Z. officinale treatment increased the activities of testicular antioxidant enzymes and restored sperm motility of cisplatin-treated rats. The protective effects of tested plants are, therefore, suggested to be mediated by their potent antioxidant activities.

Original languageEnglish
Pages (from-to)607-612
Number of pages6
JournalAsian Journal of Andrology
Volume8
Issue number5
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Cisplatin
  • Herb
  • Hibiscus sabdariffa
  • Reproductive toxicity
  • Sperm motility
  • Testicular toxicity
  • Zingiber officinale

ASJC Scopus subject areas

  • Urology

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