Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat

I. Ahmed, E. Adeghate, A. K. Sharma, D. J. Pallot, J. Singh

Research output: Contribution to journalArticlepeer-review

182 Citations (Scopus)

Abstract

An investigation was made of the effect of Momordica charantia fruit juice on the distribution and number of α, β and δ cells in the pancreas of streptozotocin (STZ)-induced diabetic rats using immunohistochemical methods. The results indicated that there was a significant (Student's t- test, P < 0.004) increase in the number of β cells in M. charantia-treated animals when compared with untreated diabetics, however, their number was still significantly less than that obtained for normal rats. There was also a significant (P < 0.006) increase in the number of δ cells in STZ-diabetic rats compared to non-diabetic rats. This increase in the number of δ cells was not affected by M. charantia treatment. The number of α cells did not change significantly in M. charantia-treated rats when compared with untreated diabetic rats. Our results suggest that oral feeding of M. charantia fruit juice may have a role in the renewal of β cells in STZ- diabetic rats or alternately may permit the recovery of partially destroyed β cells.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume40
Issue number3
DOIs
Publication statusPublished - Jun 1998

Keywords

  • Diabetes
  • Momordica charantia juice
  • Rat
  • Streptozotocin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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