Effects of Dogfish Urotensin II on Lipid Mobilization in the Fasted Dogfish, Scyliorhinus canicula

J. Michael Conlon, Loranne Agius, K. George, M. M. Alberti, Neil Hazon

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Previous studies, both in vitro and in vivo, have shown that urotensin II stimulates hepatic release of nonesterified fatty acids in teleost fish, but the effects of the peptide on lipid mobilization in elasmobranchs are unknown. Infusions of synthetic dogfish urotensin II (40 pmol/min/kg for 30 min followed by 400 pmol/min/kg for 30 min) into the first afferent gill artery of the fasted, unrestrained dogfish, Scyliorhinus canicula (n = 6), produced no significant change in the circulating concentrations of acetoacetate, 3-hydroxybutyrate, and triacylglycerols. Circulating nonesterified fatty acids were undetectable (<0.1 mmol/liter) both before and after the urotensin II infusions. There was no significant change in the circulating concentrations of glucose and lactate during either the low- or the high-dose infusions. The data support the hypothesis that lipid is converted primarily to ketone bodies in the livers of elasmobranch fish and do not indicate a role for urotensin II in regulating either lipid or glycogen mobilization.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalGeneral and Comparative Endocrinology
Volume93
Issue number2
DOIs
Publication statusPublished - Feb 1994
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

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