The complexation of sparfloxacin (SPR) and norfloxacin (NOR) by β-cyclodextrin (β-CD) in water and in mixed organic/aqueous media has been studied by absorption spectroscopy. Three organic solvents [dimethyl-sulphoxide, ethanol and 2-methyl-1-propanol have been adopted which differ in polarity and hydrophobicity. It has been shown that the presence of organic solvent causes the degradation of the 1: 1 SPR: β-CD and NOR: β-CD complexes. The binding constants of the inclusion complexes of SPR and NOR with β-CD in water are greater than those with mixed organic-water media. The higher the hydrophobicity of the co-solvent the weaker the complexation of SPR and NOR by β-CD.
|Number of pages||6|
|Journal||Asian Journal of Chemistry|
|Publication status||Published - Jan 1 2004|
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