Effect of combined maternal and infant vitamin D supplementation on vitamin D status of exclusively breastfed infants

Hussein F. Saadi, Adekunle Dawodu, Bachar Afandi, Reem Zayed, Sheela Benedict, Nicolaas Nagelkerke, Bruce W. Hollis

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Severe vitamin D deficiency in mothers and their breastfed infants is a significant health problem in the Middle East. Supplementation of the breastfed infant alone with the recommended dose of vitamin D may be insufficient in high-risk population. We investigated the effect of combined maternal and infant vitamin D supplementation on vitamin D status of the breastfed infant. We examined also the effect of supplementation on vitamin D antirachitic activity of breast milk in a subset of mothers. Healthy breastfeeding mothers (n = 90) were randomly assigned to 2000IU daily (group 1) or 60000 IU monthly (group 2) of vitamin D2, and all their infants (n = 92) received 400 IU daily of vitamin D2 for 3 months. Most infants had vitamin D deficiency - 25-hydroxyvitamin D [25(OH)D] ≤37.5 nmol L-1 - at study entry. Serum 25(OH)D concentrations at 3 months increased significantly from baseline in infants of mothers in group 1 (13.9 ± 8.6 vs. 49.6 ± 18.5 nmol L-1, P < 0.0001) and group 2 (13.7 ± 12.1 vs. 44.6 ± 15.0 nmol L-1, P < 0.0001). Maternal and infant serum 25(OH)D concentrations correlated positively at baseline (r = 0.36, P = 0.01) and 3 months (r = 0.46, P = 0.002). Milk antirachitic activity increased from undetectable (<20 IU L-1) to a median of 50.9 IU L-1. In conclusion, combined maternal and infant vitamin D supplementation was associated with a threefold increase in infants' serum 25(OH)D concentrations and a 64% reduction in the prevalence of vitamin D deficiency without causing hypervitaminosis D.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalMaternal and Child Nutrition
Volume5
Issue number1
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • 25-hydroxyvitamin D
  • Breastfed infants
  • Breastfeeding women
  • Vitamin D deficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

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